Washington, Sep 17 - Scientists
claim to have found a control switch which regulates stem cell ÒpluripotencyÓ,
the capacity of stem cells to develop into any type of cell in the human body.
An international team says the discovery
reveals that pluripotency is regulated by a single event in a process called
alternative splicing.
Alternative splicing allows one gene to
generate many different genetic messages and protein products.
The scientists found that in genetic messages
of a gene called FOXP1, the switch was active in embryonic stem cells but
silent in ÒadultÓ cells -- those that had become the specialised cells that
comprise organs and perform functions.
ÒIt opens the field to the fact that
alternative splicing plays a really important role in stem cell pluripotency,Ó
said
Prof
Benjamin Blencowe, principal investigator on the study and a Professor in the University of Toronto.
He added: ÒWe're beginning to see an entirely new landscape of regulation, which will be crucial to
our understanding of how to produce more effective pluripotent stem cells for
therapeutic and research applications.Ó The findings have been published in the
'Cell' journal.
In stem cells, scientists have shown that a
core set of proteins called transcription factors control pluripotency.
At the same time, the
mechanism represses the genes required for differentiation -- the process
whereby by a stem cell loses ÒstemnessÓ and becomes a specific cell type that
makes up an organ or performs a function.
No comments:
Post a Comment